Addressing patients' expectations via a shared decision-making process is a crucial step in optimizing nonoperative outcomes. No difference was found between the two treatment modalities in terms of perforated appendicitis rates (RR, 0.52 95% CI, 0.14-1.92), length of hospital stay (weighted mean difference, 0.20 95% CI, -0.16 to 0.56), duration of pain (WMD, 0.22 95% CI, -5.30 to -5.73), and sick leave (WMD, -2 95% CI, -5.2 to 1.1).Ĭonservative management of uncomplicated appendicitis in adults warrants further study. THE LONELY SHEPHERD - Lyrics By Alexandros Mylonas - YouTube 0:00 / 3:55 THE LONELY SHEPHERD - Lyrics By Alexandros Mylonas ALEXANDROS MYLONAS 174 subscribers 103 6.1K views 2 years ago. Lydia Fotopoulou, Akilas Karazisis, Alexandros Mylonas, Ivonni Maltezou. Overall complications were significantly higher in the surgery group (166/703 ) compared with the antibiotics group (56/727 ) (RR, 0.32 95% CI, 0.24-0.43 p < 0.001). Makis Tsoufis, Alexandros Rigas Ketty Konstadinou, Paris Thomopoulos. Correspondence address: Profile West, Suite 2, First Floor, 950 Great West Road, Brentford, England, TW8 9ES. Treatment efficacy at 1-year follow-up was significantly lower (63.8%) for antibiotics compared with the surgery group (93%) (risk ratio, 0.68 95% confidence interval, 0.60-0.77 p < 0.001). Overall, 1,430 adult patients with uncomplicated acute appendicitis underwent either nonoperative (n = 727) or operative management (n = 703). Quality assessment of included RCTs was performed using the modified Jadad scale.įive RCTs were included in this review. The random-effects model (DerSimonian-Laird) was used to calculate pooled effect estimates when substantial heterogeneity was encountered otherwise, the fixed-effects (Mantel-Haenszel) model was implemented. Data on the study design, interventions, participants, and outcomes were extracted by two independent reviewers.
The aim of this study was to synthesize evidence from randomized controlled trials (RCTs) comparing nonoperative versus surgical management of uncomplicated acute appendicitis in adult patients.Ī systematic literature search of the PubMed, Cochrane, and Scopus databases was performed with respect to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) statement (end-of-search date: January 29, 2017). 1 From the Department of Surgery (J.V.S.), Johns Hopkins University, Baltimore, Maryland Surgery Working Group (K.S.M., K.P.E.), Society of Junior Doctors, Athens, Greece Division of Pediatric Surgery, Department of Surgery (K.S.M.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts Institute of Preventive Medicine, Environmental & Occupational Health (A.G.), Prolepsis, Athens, Greece Department of Hygiene, Epidemiology and Medical Statistics (A.G.), Medical School, National and Kapodistrian University of Athens, Athens, Greece Department of Research & Innovation (S.P.S.), St Luke's University Health Network, Bethlehem, Pennsylvania Department of Surgery (C.J.B.), Brigham & Women's Hospital, Harvard Medical School, Boston, Massachusetts Department of Surgery (M.M.M.), Medical University of South Carolina, Charleston, South Carolina and Department of Surgery (K.P.E.), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.Īcute appendicitis continues to constitute a diagnostic and therapeutic challenge.He is currently in pre-production on his BFI-funded short film BUFFER ZONE and developing his first feature THE ONES LEFT BEHIND, which was one of 8 projects selected to participate at the Sundance Mediterranean Screenwriters Lab in 2018. So far Alexandros Mylonas has worked in the Hollywood entertainment industry and. Count Region Rank Mylona is quite popular family name mostly used in Greece while Cyprus is ahead in terms of density. Mylona is common in Greece country (ies). His latest short film A JAR OF NUTS, based on a story by renowned Greek author Antonis Samarakis, was funded by the Cyprus Film Fund. After many failed tries to reincarnate as a child of a caring family, he finally succeeded and was born in 87. Alexandros Mylonas is an Actor from United States. Mylona is used as a family name or surname in Greece languages. More recently, his film SUBMISSION was picked and presented by NOWNESS. As a music video director, his work was pinned by Promo News amidst the likes of Massive Attack and Florence + the Machine, and SIRENS won the Best Music Video award at Aesthetica Film Festival. His short films SONG TO THE SIREN, DOROTHEA and INTERLUDE have screened internationally at festivals, with the latter having won the Sci-Fi London Festival’s 48 Hour Film Challenge for Best Short. Savvas Stavrou is a Cypriot-British film director and alumni of the Sundance Mediterranean Screenwriters Lab, Berlinale Talents, Sarajevo Talents and Zurich Film Festival Masterclass.
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